Thursday, August 26

9.00-9.50 Networking - Virtual Coffee Meetup





10.00-10.15 Welcome & Opening Remarks


Mano Manoharan, PhD, IS3NA President
Alnylam Pharmaceuticals

Masad J. Damha, PhD, FCIC, IS3NA Immediate Past President
McGill University




10.45-11.45  Session I


Chair: Piet Herdewijn, PhD, KU Leuven

10.45-11.05
Design and Therapeutic Potential of Purinergic Receptor Ligands
Kenneth A. Jacobson, PhD, National Institute of Health

11.05-11.25
Discovery of Remdesivir and Beyond
Joy Feng, PhD, Gilead

11.25-11.45
Rapidly Advancing Transformational Therapeutic Solutions for Patients with Severe Viral Diseases
Jean-Pierre Sommadossi, PhD, Atea Pharmaceuticals




11.45-12.00  Break / Networking





12.00-13.00 Session II


Chair: Victor E. Marquez, PhD, Chemical Biology Lab, NCI, NIH

12.00-12.20
A de novo Nucleoside Synthesis: New Opportunities for Medicinal and Process Chemistry
Robert Britton, PhD, Simon Fraser University

12.20-12.40
Synthesis of Novel 2’-disubstituted Ribonucleoside Analogs
Franck Amblard, PhD, Emory University

12.40-13.00
TBA




13.00-13.30 Discussion


Chairs: Victor E. Marquez, PhD, Chemical Biology Lab, NCI, NIH & Piet Herdewijn, PhD, KU Leuven




13.30-13.45 Break / Networking





13.45-14.45  Session III


Chair: Katherine Seley-Radtke, PhD, University of Maryland, Baltimore County Student/Postdoc Talks to be selected from submitted abstracts




14.45-15.45 Session IV


Chair: Jean-Jacques Vasseur, PhD, Université de Montpellier

12.00-12.20
Enzymatic Photocaging of Nucleic Acids: A Strategy for Controlling Methyltransferase Target Sites by Light
Andrea Rentmeister, PhD, University of Münster

12.20-12.40
Stealth Fluorescence Labeling for Live-Cell Imaging in RNA-based Therapeutics
Marcus Wihelmsson, PhD, Chalmers University Technology

12.40-13.00
TBA
Olalla Vázquez, PhD, Philipps-Universität Marburg




15.45-16.45 Virtual Networking & Social Meetups





10.15-10.45 Keynote Presentation


Therapeutic Nucleosides and Evolution of Oligonucleotide Synthesis
Professor Kelvin Ogilvie, Acadia University





Friday, August 27

9.00-9.50 Networking - Virtual Coffee Meetup





10.00-11.40 Session V


Chair: Steve Dowdy, PhD, University of California, San Diego 10.00-10.20
Development of Sugar-modified Oligonucleotides with Higher Enzymatic Stability Than PS Oligonucleotides
Satoshi Obika, PhD, Osaka University 10.20-10.40
PNAs with Double Face: Bimodal PNAs as Templates for Supramolecular Assemblies of Nucleic Acids
Krishna N. Ganesh, FNA, FASc, FTWAS, Indian Institute of Science Education and Research 10.40-11.00
Novel DNA-boron Cluster Conjugates with Two Faces
Barbara Nawrot, PhD, Polish Academy of Sciences 11.00-11.20
Improved Specificity of Conjugate siRNAs Through Chemical Modification
Mark K. Schlegel, PhD, Alnylam Pharmaceuticals 11.20-11.40
Oligonucleotides Based Approaches for Treatment of Chronic Hepatitis B
Leonid Beigelman, PhD, Aligos Therapeutics




11.40-12.00 Discussion


Chair: Steve Dowdy, PhD, University of California, San Diego




12.15-13.15 Session VI


Chair: Suzanne Peyrottes, PhD, Université de Montpellier Student/Postdoc Talks to be selected from submitted abstracts




15.10-15.30 Discussion


Chair: Yitzhak Tor, PhD, University of California, San Diego




13.15-13.30 Break / Networking





13.30-15.10 Session VII


Chair: Yitzhak Tor, PhD, University of California, San Diego 13.30-13.50
A Natural Riboswitch Scaffold with Methyltransferase Activity
Ronald Micura, PhD, University of Innsbruck 13.50-14.10
TBA
14.10-14.30
RNA Functionalization via an Expanded Genetic Alphabet
Stephanie Kath-Schorr, PhD, University of Cologne 14.30-14.50
Ribozyme Gene Switches for Biosensing and Regeneration Studies
Maureen McKeague, PhD, McGill University 14.50-15.10
TBA
Bradley L. Pentelute, PhD, Massachusetts Institute of Technology




15.30-15.35 Closing Remarks


Mano Manoharan, PhD, IS3NA President
Alnylam Pharmaceuticals

Masad J. Damha, PhD, FCIC, IS3NA Immediate Past President
McGill University




15.35-16.45 Virtual Networking & Social Meetups





12.00-12.15 Break / Networking