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Job Opening: Scientist, Oligonucleotide Chemistry, Aligos Therapeutics


Aligos Therapeutics, Inc. is a biotechnology company located in South San Francisco, California that is developing novel medicines to treat liver diseases in virology, inflammation/fibrosis, and oncology. Aligos is pursuing the development of both oligonucleotide-based and small molecule therapeutics, each addressing major commercial market opportunities.


At Aligos, our science is the key to our success, and to improving patients' quality of life. Our pipeline of developing novel compounds and investigative therapies reflects our commitment to bring innovative products to patients with unmet needs in the area of liver diseases. This is an exciting opportunity to become an early employee of a high energy, Research and Development company. We are looking for an enthusiastic professional who understands and appreciates the entrepreneurial environment of a “start-up” and who is willing to do what it takes to contribute to the success of the company”.

Position Summary/About the Team:


The Scientist Oligonucleotide Chemistry will assist in discovery and scale-up activities related to oligonucleotides, specifically of multiple compounds at the milligram scale and single compounds at the gram scale. This individual must have experience in oligonucleotide synthesis.


Essential Functions / Responsibilities:

  • Synthesis, deprotection, purification, desalting and lyophilization of oligonucleotides to support projects in multiple disease areas.

  • Track progress against project timelines, generate regular status updates, and communicate progress and problems at team meetings.

  • Conduct laboratory work in an efficient manner that ensures a safe working environment for yourself and your colleagues.

  • Possess an excellent work ethic with the ability to work as part of a team.

  • Maintain a well-documented laboratory notebook and follow the safe laboratory practices.

  • Multi-task across several projects and manage time effectively to achieve results.

  • Analyze and interpret data.

  • Operate and maintain lab instruments such as HPLC/UHPLC, LC/MS, tangential flow filtration (TFF) system and UV-Vis spectrophotometer.

Reasonable accommodations may be made to enable individuals with disabilities to perform these essential functions.


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