XX IRT Scientific Programme

More than 38 reasons to attend


38 invited and contributed talks are planned and we anticipate more than 300 posters.
Afternoon poster sessions are on Monday Aug 6 and Tuesday Aug 7

Download the abstracts for Monday’s presentations
Download the abstracts for Tuesday’s presentations
Download the abstracts for Wednesday’s presentations
Download the abstracts for Thursday’s presentations
Download the Catalogue of Poster Presentations

A listing of all poster abstracts may be found here.  
To view the poster abstracts, please select from the categories below:

Medicinal Chemistry of Nucleos(t)ides
Medicinal Chemistry of Oligonucleotides
Nucleos(t)ide Probes
Macromolecular Structure and Function
Chemical and Systems Biology
Supramolecular Structures and Functional Nucleic Acids



Nucleosides (medicinal chemistry/mechanisms)
Oligonucleotides (medicinal chemistry/mechanisms)
Structure/Macromolecular Recognition
Biochemistry/Chemical and System Biology/Evolution
Supramolecular/Functional Nucleic Acids
Probes, Methods and Nucleoside/Nucleotide Reagents

Plenary Speakers

Jack Szostak - Howard Hughes Medical Institute, USA
Non-enzymatic RNA replication and the origin of life
 (Supported by RSC Publishing)
Frank Seela – University of Osnabrück, Germany
A journey from modified nucleosides to DNA
Imbach-Townsend Award Lecture
(Supported by Idenix Pharmaceuticals)
Akira Matsuda – Hokkaido University, Japan
Development of sugar-modified cytosine nucleosides as antitumor agents: old stories for furture success
John A Montgomery Award Lecture
(Supported by the Center for Drug Design, University of Minnesota)


Invited Speakers

Serge Beaucage US Food and Drugs Administration, USA
Reversible ribonucleoside 2'-modifications for either RNA labeling or RNA synthesis
Frank Bennett – Isis Pharmaceuticals, USA
Effects of chemical modifications on molecular mechanisms of antisense oligonucleotides
Tom Brown – University of Southampton, UK
Click nucleic acid ligation:  chemistry, biochemistry and applications
Cynthia Burrows – University of Utah, USA
Single-molecule studies of oxidative damage in telomeric G quadruplexes
David Corey – UT Southwestern Medical Center, USA
Allele selective inhibition of mutant Huntington expression
Martin Egli – Vanderbilt University, USA
Correlating 3D-structure, stability and activity of chemically modified nucleic acids
Carlos González – Instituto de Química-Física Rocasolano. CSIC, Spain
Effects of fluorine and other substitutions on duplex and quadruplex structures studied by NMR
Matthias Götte – McGill University, Canada
Mechanism of action of nucleotide-competing RT inhibitors
Michal Hocek – Academy of Sciences of the Czech Republic, Czech Republic
Base-modified nucleosides and nucleotides as new cytostatics or building blocks for polymerase synthesis of functionalized nucleic acids
Eric Kool – Stanford University, USA
Fluorescent nucleic acids as chemical tools for biology
Emily Leproust – Agilent, USA
The synthesis of ultra-long-mer oligo pools from high-fidelity microarrays
Muthiah Manoharan – Alnylam Pharmaceuticals, USA
Systemic delivery of siRNAs using multivalent carbohydrate conjugates
Katherine Seley-Radtke – University of Maryland, Baltimore County, USA
Structural diversity in nucleoside drug design
Dinshaw Patel – Memorial Sloan-Kettering Cancer Center, USA
Structural biology of small RNA-mediated gene regulation
Enrique Pedroso –  University of Barcelona, Spain
Synthesis of conformationally constrained oligonucleotides
Oliver Seitz – Humboldt-University zu Berlin, Germany
DNA programmed chemistry and assemblies for the life sciences
Hanadi Sleiman – McGill University, Canada
3D DNA structures:  loading and selective release of cargo and enhanced cellular uptake
Michael Sofia – Gilead Sciences, USA
2'F, 2'C-methyl nucleotide prodrugs for the treatment of HCV infection:
 from discovery to the clinic
David Standring – Idenix Pharmaceuticals Inc, USA
IDX184 and novel nucleotides for the treatment of HCV
Peter Strazewski – University Claude Bernard Lyon 1, France
RNA anchored to giant lipid vesicles:  a systemic approach toward the evolution of translation


Oral Presentations (selected from abstracts)

Marvin Caruthers University of Colorado, USA
New DNA analogs – synthesis, biological and chemical properties
John Chaput Arizona State University, USA
An artificial genetic system capable of Darwinian evolution
Robert Hudson – University of Western Ontario, Canada 
Expanding the nucleic acid chemist’s toolbox: pyrrolocytosine and congeners
Sergei Gryaznov Geron Corporation, USA
How does telomerase recognize its substrates?
David Hodgson – Durham University, UK
Aqueous phosphorylation and nucleoside transformations: synthesis of initiators for the preparation of 5’-labelled RNAs
Annemieke Madder – Ghent University, Belgium
Furan-based oligonucleotides for cross-linking at the DNA/DNA and DNA/protein interface
Maureen McKeague – Carleton University, Canada
Trends in aptamer selection for small molecular targets
Chris Meier – University of Hamburg, Germany
Development of lipophilic prodrugs of nucleoside mono-, di-, and triphosphates as potential antiviral agent
Eric Montemayor University of Texas Health Science Center, USA
Structural basis of lariat RNA recognition by the intron debranching enzyme, DBR1
Poul Nielsen – University of Southern Denmark, Sweden
Nucleic acid structures based on double-headed nucleosides
Marleen Renders University of British Columbia, Canada
A novel method for the selection of modified DNAzymes
Eriks Rozners Binghamton University, USA
Sequence selective recognition of double helical RNA using PNA
Jean-Jacques Vasseur – Université Montpellier, France
DNA-templated dynamic ligation of borononucleic acids
Shinsuke Sando – Kyushu University, Japan
Fluorescence imaging of extracellular chemical transmitter dynamics using synthetic aptamer sensor
Hongbin (Tony) Yan – Brock University, Canada
Cyclic dinucleotides as mucosal vaccine adjuvants


Imbach-Townsend Award, and Montgomery Award

The Imbach-Townsend award is supported by Idenix Pharmaceuticals and the Montgomery award is supported by the Center for Drug Design, University of Minnesota.

Poster Awards

Thanks to generous support from Alios BioPharma, Current Protocols (John Wiley) and Nucleic Acids Research (Oxford University Press), several poster cash prizes will be awarded.  The awardees will be selected by the Posters and Travel Awards Committee of IS3NA.


Symposium Schedule

The programme will include 3 plenary/award lectures (PL) of 45 min, 20 invited lectures (IL) of 35 min, and 15 short oral presentations (OP) of 25 min. The posters will be accessible throughout the conference. On Sunday, 5th August, registration will open at 17:00 and will be followed by a welcome reception.

  Mon 6 Aug Tue 7 Aug Wed 8 Aug Thu 9 Aug
Start 08:15 08:30 08:30 08:30
morning session
Intro IL7 IL13 IL16
PL1 OP5 OP10 IL17
IL1 IL8 IL14 OP11
OP1   IL15 OP12
Refreshments 10:15 10:05 10:40 10:30
morning session
OP2 OP6 IS3NA  report IL18
IL3 IL10 XX IRT 2014  
Lunch 12:20 12:10 12:35 12:25
afternoon session
IL4 IL11 Social programme IL19
OP3 OP7 OP13
IL5 IL12 IL20
Refreshments 15:25 15:25 15:35
Second afternoon session OP4 OP8 OP14
IL6 OP9 OP15


Poster session 17:00 17:00  
Close 19:30 19:30 17:00
18:30     Drinks reception*  
19:15     Conference Banquet*  
* Note: Drinks Reception & Conference Banquet are for banquet ticket holders

Download the abstracts for Monday’s presentations
Download the abstracts for Tuesday’s presentations
Download the abstracts for Wednesday’s presentations
Download the abstracts for Thursday’s presentations
Download the Catalogue of Poster Presentations

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